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Monogenic and Multifactorial Autoinflammatory Disorders International Advanced Course

Eventi Nazionali ed Internazionali
Data: Giovedì 14 Dicembre 2017 - Sabato 16 Dicembre 2017

Luogo: sala convegni Hotel degli Ulivi  |  Città: Siena, Italia

programma da confermare


During the Course on “Monogenic and Multifactorial Autoinflammatory Disorders” to be held in Siena on December 14th-16th 2017, we will gather some of the leading experts in this field.
We will discuss about new insights on the pathogenesis of monogenic and multifactorial autoinflammatory diseases, their clinical manifestations and differential diagnosis.
A great emphasis will be placed on their different clinical presentations in children and adults.
Moreover, we will discuss about novel potential treatment targets and new indications for old therapies that have recently emerged from the real life experience. An exclusive session will be entirely dedicated to Behcet’s disease, while another session will be focused on the eye involvement in different systemic inflammatory disorders. It will be a unique meeting where young scientists and clinicians will mingle with the stars to have very hot and intriguing discussions. We are all looking to seeing you at this meeting in Siena!

Luca Cantarini and Mauro Galeazzi


Claudia Fabiani (Milan)
Stefano Gentileschi (Siena)
Giuseppe Lopalco (Bari)
Orso Maria Lucherini (Siena)
Ida Orlando (Siena)
Jurgen Sota (Siena)
Antonio Vitale (Siena)

Ranuccio Nuti

Mauro Galeazzi
Bruno Frediani

Luca Cantarini

Claudia Fabiani


Juan I. Arostegui (Barcelona, Spain)
Chiara Baldini (Pisa, Italy)
Eldad Ben-Chetrit (Jerusalem, Israel)
Bahram Bodaghi (Paris, France)
Antonio Brucato (Bergamo, Italy)
Luca Cantarini (Siena, Italy)
Marco Cattalini (Brescia, Italy)
Giulio Cavalli (Milan, Italy)
Rolando Cimaz (Florence, Italy)
Luca Cimino (Reggio Emilia, Italy)
Francesco Di Virgilio (Ferrara, Italy)
Giacomo Emmi (Florence, Italy)
Claudia Fabiani (Milan, Italy)
Bruno Fautrel (Paris, France)
Ennio Giulio Favalli (Milan, Italy)
Michele Fimiani (Siena, Italy)
Bruno Frediani (Siena, Italy)
Mauro Galeazzi (Siena, Italy)
Marco Gattorno (Genova, Italy)
Salvatore Grosso (Siena, Italy)
Gulen Hatemi (Istanbul, Turkey)
Christian M. Hedrich
(Dresden, Germany)
Dirk Holzinger (Münster, Germany)
Jasmin B. Kuemmerle-Deschner
(Tübingen, Germany)
Isabelle Konè-Paut (Paris, France)
Florenzo Iannone (Bari, Italy)
Luca Idolazzi (Verona, Italy)
Pietro Enea Lazzerini (Siena, Italy)
Helen J. Lachmann
(London, United Kingdom)
Franco Laghi Pasini (Siena, Italy)
Ennio Lubrano (Campobasso, Italy)
Raffaele Manna (Rome, Italy)
Giuseppe Matarese (Naples, Italy)
Elisabetta Miserocchi (Milan, Italy)
Piergiorgio Neri (Ancona, Italy)
Laura Obici (Pavia, Italy)
Francesca Oliviero (Padova, Italy)
Carlo Perricone (Rome, Italy)
Nicolò Pipitone (Reggio Emilia, Italy)
Roberta Priori (Rome, Italy)
Leonardo Punzi (Padova, Italy)
Donato Rigante (Roma, Italy)
Pietro Rubegni (Siena, Italy)
David Saadoun (Paris, France)
Carlo Salvarani (Reggio Emilia, Italy)
Annalisa Santucci (Siena, Italy)
Petros P. Sfikakis (Athens, Greece)
Paolo Sfriso (Padova, Italy)
Rosaria Talarico (Pisa, Italy)
Alberto Tommasini (Trieste, Italy)
Gian Marco Tosi (Siena, Italy)
Désirée Van Der Heijde
(Leiden, The Netherlands)
Lorenzo Vannozzi (Firenze, Italy)

14:00 Registration
14:20 Welcome address by Local and Regional authorities
Bruno Valentini, Mayor of Siena
Stefano Scaramelli, President of the III Health Commission of the
Tuscany Region
Cecilia Berni, Regional Coordination of Rare Diseases
of the Tuscany Region
Francesco Frati, Chancellor of the University of Siena
Pier Luigi Tosi, General Manager of “Santa Maria alle
Scotte” University Hospital
Roberto Monaco, President of the Association of Medical and
Dental Surgeons of Siena
Ranuccio Nuti, Head of the Department of Medical Sciences, Surgery
and Neurosciences
14:50-14:55 Welcome address by the President of the Italian Society of
Mauro Galeazzi
14:55-15:00 Welcome address by the Secretary of the Autoinflammatory
Diseases Working Group of the Italian Society of Rheumatology
Luca Cantarini

15:00-15:30 Opening Lecture
Role of the Inflammasome in the pathogenesis of Chronic
Inflammatory diseases
Francesco Di Virgilio
15:30-16:00 Opening Lecture
Interplay among Metabolism, Inflammation and Immunologic
Tolerance - Giuseppe Matarese
I Session: Axial Spondyloarthritis and Psoriatic Arthritis
Chairs: Bruno Frediani, Mauro Galeazzi
16:00-16:30 Lecture
The ASAS-EULAR management recommendations for axial
spondyloarthritis - Désirée Van Der Heijde
16:30-16:45 TNF-alpha inhibitors for axial spondyloarthritis - Ennio Lubrano
16:45-17:00 New Pathways and Emerging Treatments for Axial
Spondyloarthritis - Ennio Giulio Favalli
17:00-17:15 What’s New with TNF-α inhibitors for psoriatic arthritis: update
Luca Idolazzi
17:15-17:30 Emerging drugs for psoriatic arthritis - Florenzo Iannone
17:30-17:45 Cardiovascular risk in patients with chronic inflammatory arthritis.
The Role of Biologic Therapy - Petros P. Sfikakis
17:45-18:00 Systemic inflammation and arrhythmic risk: lessons from chronic
inflammatory arthritis - Pietro Enea Lazzerini
18:00-18:10 Discussion

II Session: Monogenic Autoinflammatory disorders (section I)
Chairs: Raffaele Manna, Marco Gattorno
08:30-08:45 Familial Mediterranean fever - Eldad Ben-Chetrit
08:45-09:00 TRAPS syndrome - Helen J. Lachman
09:00-09:15 Cryopyrin-associated periodic syndromes
Jasmin B. Kuemmerle-Deschner
09:15-09:30 Hyper-IgD syndrome - Alberto Tommasini
09:30-09:45 Reactive Amyloidosis in Autoinflammatory Disorders - Laura Obici
09:45-10:00 Somatic mosaicism in Monogenic Autoinflammatory Diseases
Juan I. Arostegui
10:00-10:10 Discussion
10:10-10:40 Coffee break
III Session: Monogenic Autoinflammatory disorders (section II)
Chairs: Donato Rigante, Leonardo Punzi
10:40-11:00 Lecture
Autoinflammatory diseases in adults - Luca Cantarini
11:00-11:20 Lecture
The differential diagnosis of Hereditary Periodic Fever Syndromes
Raffaele Manna
11:20-11:35 Early Onset Sarcoidosis/Blau Syndrome - Leonardo Punzi
11:35- 11:50 Chronic recurrent multifocal osteomyelitis - Christian M. Hedrich
11:50-12:05 Interferonopathies - Marco Cattalini
12:05-12:20 Biomarkers in Systemic Autoinflammatory disorders
Dirk Holzinger
12:20-12:30 Discussion
12:30-13:40 Lunch
IV Session: Multifactorial Autoinflammatory disorders
Chairs: Salvatore Grosso, Rolando Cimaz
13:40-14:00 Lecture
Classification of Systemic Monogenic and Multifactorial
Autoinflammatory Diseases: update - Marco Gattorno
14:00-14:15 PFAPA syndrome between Childhood and Adulthood - Donato Rigante
14:15-14:30 Systemic Onset Juvenile Idiopathic Arthritis (SOJA) - Rolando Cimaz
14:30-14:45 Adult Onset Still’s Disease (AOSD) - Bruno Fautrel
14:45-15:00 IL-37: a new frontier in auto-inflammatory syndromes?
Giulio Cavalli
15:00-15:10 Discussion
15:10-15:30 Coffee Break
V Session: The Eye between Autoimmunity and Autoinflammation
Chairs: Gulen Hatemi, Luca Cantarini
15:30-15:45 Eye involvement in Monogenic and Multifactorial
Autoinflammatory Disorders - Bahram Bodaghi
15:45-16:00 Innate and Adaptive immune mechanisms in Uveitis:
Autoimmunity and Autoinflammation - Piergiorgio Neri
16:00-16:15 TNF-inhibition in Behcet’s disease related uveitis - David Saadoun
16:15-16:30 IL-1 inhibition in Behcet’s disease related uveitis. - Claudia Fabiani
16:30-16:50 Coffee break
16:50-17:05 The management of anterior uveitis in ankylosing spondylitis
Luca Cimino
17:05-17:20 Dry Eye Disease and IL-1: pathogenesis and potential treatment
Chiara Baldini
17:20-17:35 Vitreoretinal Surgery in the management of patients with uveitis
Gian Marco Tosi
17:35-17:50 Intravitreal Treatment of Macular Edema in Chronic Non-infectious
Uveitis: state of the art - Lorenzo Vannozzi
17:50-18:00 Discussion

VI Session: Behcet’s disease
Chairs: Carlo Salvarani, David Saadoun
08:30-09:00 Lecture
Behcet’s disease - Carlo Salvarani
09:00-09:30 Lecture
Outcome measures in Behcet’s disease - Gulen Hatemi
09.30-09:45 Behcet’s disease in children - Isabelle Konè-Paut
09:45-10:00 Neurophsychiatric involvement in Behcet’s disease
Rosaria Talarico
10:00-10:15 Vascular involvement in Behcet’s disease - Giacomo Emmi
10:15-10:25 Discussion
10:25-10:45 Coffee Break
VII Session: Miscellaneous
Chairs: Michele Fimiani, Franco Laghi Pasini
10:45-11:00 Biologic Therapy in Jia Associated Uveitis
Elisabetta Miserocchi
11:00-11:15 Giant cell arteritis and novel therapeutic perspectives
Nicolò Pipitone
11:15-11:30 Idiopathic Recurrent Acute Pericarditis - Antonio Brucato
11:30-11:45 Gout as an autoinflammatory disorders: New mechanisms for
more appropriated treatment targets - Francesca Oliviero
11:45-12:00 The Autoimmune/inflammatory syndrome induced by adjuvants
(ASIA - Carlo Perricone
12:00-12:15 Schnitzler Syndrome: from pathogenesis to IL-1 inhibition
Pietro Rubegni
12:15-12:30 Alkaptonuria: New Pathways and Potential Treatment Targets
Annalisa Santucci
12:30-12:40 Discussion
VIII Session: Conclusive Session
Chairs: Marco Gattorno, Donato Rigante
Short Communications from the Autoinflammatory Diseases Working
Group of the Italian Society of Rheumatology (S.I.R)
12:40-12:50 Efficacy and Safety of Anakinra and Canakinumab in AOSD. (4th Study)
Roberta Priori
12:50-13:00 On- and Off-label use of Anakinra and Canakinumab in Italy
A Nationwide Multicenter Study. (3rd Study) - Luca Cantarini
13:00-13:10 Adult-onset Still’s Disease in Italy. A Multicenter Study. (2nd Study)
Paolo Sfriso
13:10-13:20 Discussion and conclusions
13:20 Light Lunch

Hotel Siena degli Ulivi
Via Antonio Lombardi, 41, 53100 Siena, Italy
Ph. +39 0577 5577

For hotel booking please contact the Organizing Secretariat:
Alessandra Grossi | Questo indirizzo email è protetto dagli spambots. E' necessario abilitare JavaScript per vederlo.

The course is free and open to a limited number of participants.
It is mandatory to register before the event, filling out the online application form, which will be available soon

For sponsorships please contact organizing secretariat:
Valentina Nizzolari | Questo indirizzo email è protetto dagli spambots. E' necessario abilitare JavaScript per vederlo.

MCO International Group Srl (CME Provider n. 5535) will assign to the conference the CME credits according to Italian Health Ministry’s criteria.
CME credits will only be awarded to Italian delegates: Medical Doctors
[Cardiology, Dermatology, Infectious diseases, General medicine, Internal Medicine, Neurology, Ophthalmology, Pediatrics, Rheumatology].


Via Antonio Lombardi, 41
53100 Siena SI, Italia


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  • Da Giovedì 14 Dicembre 2017 a Sabato 16 Dicembre 2017

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